|
KMID : 0376219730100030861
|
|
Chonnam Medical Journal
1973 Volume.10 No. 3 p.861 ~ p.869
|
|
|
Effects of some autonomic drugs on the trigone-detrusor muscle strips of the urinary bladder of the rabbits
|
|
|
|
|
Abstract
|
|
|
It has been well known that the urinary, bladder is a hollow organ which can evacuate urine under the autonomic innervation. However, physiologic significance of sympathetic innervation has not been fully understood. It was also-reported that stimulation of the hypogastric nerve or the administration of catecholamine-produce an initial contraction followed by relaxation of the-urinary bladder. These effects were ascribed to the different adrenergic receptors in the trgoneand detrusor muscle the trigone muscle contains alpha-receptors and the detrusor beta-receptors.
In the previous experiments of other authors, the isolated muscle strips of the trigone and detrusor muscle were used independantly. In this experiments, effects off some, autonomic drugs on the trigone-detrusor muscle strips were studied to elucidate the significance of the sympathetic innervations. In addition, the effects of stimulation-frequencies on the hypogastric-urinary bladder preparation were also studied. The results obtained were as follows:
1. Stimulation of the hypogastic nerve in situ elicited an initial contraction followed by re1axation of the urinary bladder. This excitatory-response was due to the trigone-muscle and the inhibitory response due to the detrusor muscle. These excitatory and inhibitory responses were most effective in the stimulus frequencies from 50 to 60 cps.
2. The administration of norepinephrine or epinphrine on the trigone-detrusor muscle strip evoked an initial contraction followed by relaxation. The contraction caused by the trigone-muscle proceeded the relaxation caused by the detrusor muscle.
3. The excitatory response to norepinephrine or epinephrine on the trigone detrusor muscle strip a completely abolished by the ´pretreatment with regitine or phenoxybenzamine, the adrenergic alpha-receptor blocking agents, and the inhibitory response was also completely blocked by the pretreatment of propranolol or dichloroisoproterenol, the adrenergic beta-receptor blocking agents.
4. These experimental evidences suggest that the excitation of hypogastric nerve to the urinary bladder may increase the intravesical capacity for the storage of urine.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|